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Dialysis world news


New MRI technique can follow changes in brain pH.
EurekAlert: According to Wemmie, the new imaging technique provides the best evidence so far that pH changes do occur with normal function in the intact human brain. The findings were published May 7 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition. Specifically, the study showed the MRI-based method was able to detect global changes in brain pH in mice. Breathing carbon dioxide, which lowers pH (makes the brain more acidic), increased the signal, while bicarbonate injections, which increases brain pH, decreased the MRI signal. The relationship between the signal and the pH was linear over the range that was tested. Importantly, the method also seems able to detect localized brain activity. When human volunteers viewed a flashing checkerboard -- a classic experiment that activates a particular brain region involved in vision -- the MRI method detected a drop in pH in that region. The team also confirmed the pH drop using other methods. "Our study tells us, first, we have a technique that we believe can measure pH changes in the brain, and second, this MRI-based technique suggests that pH changes do occur with brain function," Magnotta says.

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Mouse study suggests benefits of scheduled eating.
EurekAlert: To find out whether restricted feeding alone, without a change in calorie intake, could prevent metabolic disease, Panda's team fed mice either a standard or high-fat diet with one of two types of food access: ad lib feeding or restricted access. The time-restricted mice on a high-fat diet were protected from the adverse effects of a high-fat diet and showed improvements in their metabolic and physiological rhythms. They gained less weight and suffered less liver damage. The mice also had lower levels of inflammation, among other benefits.

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Renal denervation shows encouraging results for resistant hypertension.
EurekAlert: The investigators performed renal denervation in 15 patients with hypertension and CKD. Normal blood pressure in the general population is 120/80 mmHg. Patients' average level at the start of the study was 174/91 mmHg despite taking numerous antihypertensive drugs. Patients' blood pressure readings dropped considerably at one, three, six, and 12 months after the procedure (-34/-14, -25/-11, -32/-15, and -33/-19 mmHg, respectively). Renal denervation did not worsen patients' kidney function, indicating that it is safe even when CKD is present. "These initial findings now open up an entirely new approach to better control blood pressure in CKD and potentially slow down progression of CKD and reduce cardiovascular risk in these patients. said Dr. Schlaich.

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What a 'man': 'Rare breed', oldest living kidney donor! - Daily Bhaskar

Nicholas Crace, the 83-year old man who is fit and healthy, shows the world how a living human being can rise above the life-and-death concept and serve the humanity with whatever possible means he has. The UK-based man has recently donated one of his kidneys to a person he did not even know and perhaps would never know. He has donated blood 57 times and is a volunteer driver for a local hospice.

“I knew that 7,000 people are waiting for a kidney and that one person dies almost every day while waiting.  ….Giving a small part of me to someone else will make little difference to my life but a huge difference to someone else's. I was lucky to be in a position to help someone else less fortunate than myself," the man was quoted as saying to theguardian in UK.

Crace was aware of the difficulties faced by patients on dialysis – regular trips to hospital, a restricted diet and health problems. He said it was an easy decision to become a donor.

Over a period of six months, he made 14 visits to Queen Alexandra hospital in Portsmouth – a round trip of nearly 100 miles – for tests, checks and a three-hour operation to remove a kidney. Within three days of the operation he was back mowing the lawn and riding his bike, theguardian reported.

Sam Dutta, the surgeon who performed the operation, said, "We know from numerous studies that a living-donor kidney performs better, works quicker and lasts longer than one from a deceased donor. All the detrimental factors related to being on dialysis are completely taken care of by a good functioning kidney. An altruistic donor coming forward is an amazing thing for us. The recipient just gets a new lease of life."

Crace is one of a rare breed – just 100 people in the UK have donated a kidney while living, for someone they are never likely to know.




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Jackson County woman who has been on dialysis nearly 35 years called a miracle - The Jackson Citizen Patriot - MLive.com

mjm_51612_dialysis.zip Diana Doxtader is nearing a world record, but it isn’t an enviable one.

The Springport woman marked 35 years on dialysis on Monday. That means she has been hooked to a machine three times a week since then, four hours per visit, to remove her blood, clean it and remove the waste, then return it to her body.

“I feel pretty special that I’m able to still be alive,” she said.

Doxtader, 63, is among the longest-living people in the world on dialysis, according to Marcie Gerlach, communications manager for the National Kidney Foundation of Michigan in Ann Arbor.

“She is a miracle,” said Dr. Reddivalem Nagesh, who began treating Doxtader when he opened his Jackson practice in 1980.

Doxtader, a small woman with an amazing memory, was a single mother of two children, ages 4 and 8, when high blood pressure shut down her kidneys. High blood pressure – hers was in the 200’s – and diabetes are the leading causes of kidney disease.

“I was 28-years-old, on welfare, scared and frightened,” said Doxtader, her legs covered with a blanket, her head against a pillow, as she received dialysis one recent morning at DSI, 200 S. East Ave.

Jackson didn’t have a dialysis center in 1977 so Doxtader drove to Coldwater, a six-hour ordeal between the drive and treatment, three times a week.

A couple things changed to make life a bit easier: in 1978 she married Richard Doxtader, and a dialysis center opened in Jackson in 1982.

As she talked about infections, breaking both hips and last year suffering a stroke that put her in a coma for four days— all due to the way dialysis ravages the body— Doxtader smiled about the fun times she and Richard, 68, who retired from Hayes Albion, have had together.

For 10 years they joined other couples most summer weekends where they tent camped and drove four-wheelers or Jeeps along 200 miles of trails near Cadillac. They often played blind man’s bluff, Diana driving blindfolded and the woman seated next to her giving directions of when to turn or go straight. Or they played hide-and-seek using CB radios.

“We left our campsite early, packed a lunch and didn’t get back until dark,” she said. They were also on four bowling leagues.

Doxtader just shrugged her shoulders when she talked about two failed kidney transplants, in 1981and 1982. The first one lasted just over three months, the second only two days.

Her husband is more vocal.

“You wouldn’t wish this on nobody. It’s horrible,” said Richard, reaching for Diane’s hands and showing how twisted they are now from the dialysis. She can no longer crochet, a favorite pastime.

They leave their home by 5:15 a.m. on Mondays, Wednesdays and Fridays and he wheels her inside in a wheelchair. Once she is in her chair for her treatment that begins at 6 a.m., he leaves to work out at Allegiance Health’s Wellness Center.

When they get home, Diana said she often sleeps for several hours because she is so exhausted.

Thursdays Richard cleans the house – Diana can only dust – and does their laundry. Once a month they meet other Hayes-Albion retirees and their spouses for lunch at Denny’s, and one night a month they treat themselves to dinner out, usually Old Country Buffet.

“I really try to follow the diet but it is hard,” said Diana. “You have to avoid salt, cheese, milk products, meats with a lot of salt.”

Donna Miller, charge nurse at DSI, said being put on dialysis is “life-changing, from what you eat and drink to needing four-hour treatments three times a week to lots of medical problems over time.”

“Patients feel like they are losing control over their life,” she said.

The Kidney Foundation’s Gerlach said the emphasis is on “prevention. You don’t want to go down the path of kidney disease.” Last year there were nearly 13,500 people in Michigan on dialysis, she said.

Nagesh, Doxtader’s nephrologist, said newer medical treatments are helping some dialysis patients live longer, but to have someone be on dialysis “beyond 30 years is very unusual because of how toxins affect the blood, bones, organs of the body. Heart disease is a common complication of kidney disease.”

For Doxtader, advice she got 35 years ago from a fellow patient in Coldwater has helped her cope.

“She told me take it one day at a time and that’s how I’ve always lived because I don’t know if I’ll be here tomorrow.”

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