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Metformin for CKD? A contrarian point of view. |
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Nephron Clinical Practice (Nye and Herrington): Critical review of this literature calls into question the validity of these claims, with metformin usually acting as an ‘innocent bystander’ in acutely unwell patients with conditions well recognised to precipitate lactic acidosis such as sepsis or hypovolaemia. In fact, the evidence supports the safe use of appropriate doses of metformin in patients with chronic stable renal impairment, and highlights the important possible greater risks of the alternatives, most notably severe hypoglycaemia in patients taking sulphonylureas and/or insulin and fluid retention in patients taking a thiazolidinedione.
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Ecuardorean Sephardic remnant populations with Laron dwarfism live long diabetes- and cancer-free lives. |
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NY Times: People living in remote villages in Ecuador have a mutation that some biologists say may throw light on human longevity and ways to increase it.
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Of interest to balding nephrologists only. |
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ABC news: The authors suggest that temporarily blocking CRF receptors could be "a breakthrough therapy for alopecia," and might also hold potential for male pattern baldness and hair loss due to chemotherapy. "What we can reasonably say is that the antagonist initiates the hair cycle," Million said. "In bald individuals, and in these mice, the hair follicles are in a resting stage. The antagonist awakes them. It turns on the cycle, and the growing phase starts." The treatment not only reversed hair loss, it also prevented it if started ahead of time. It also restored pigmentation in the skin -- an effect Million said might prevent graying too.
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Coach gives of himself so student can play -- and live - Bucyrus Telegraph Forum |
Bucyrus Telegraph Forum
He was spending nine hours a day on a dialysis machine. He needed a transplant. No family members were a match. When Walter heard about the illness, he got himself checked. Before anything good could happen, the folks at Wake Forest had to check with
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MagicKitchen.com Gives Dialysis and Renal Patients a Reason to Rejoice - PR-USA.net (press release) |
PR-USA.net (press release)
When MagicKitchen.com introduced its expanded and further developed menu of renal and dialysis-friendly meals last month, patients across the country raced to place orders for meals that suited their specific dietary requirements.
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