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Pfizer renal cell carcinoma therapy receives positive opinion from CHMP - Pharmaceutical Business Review |
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PBR Staff Writer
Published 28 May 2012
Pfizer has received positive opinion from the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency for the marketing authorization of axitinib to treat patients with advanced renal cell carcinoma.
The European Commission, which has the authority to approve medicines for the EU, will review CHMP's positive opinion.
Pfizer Oncology Business Unit clinical development and medical affairs senior vice president Mace Rothenberg said that CHMP has adopted a positive opinion for axitinib as a second-line treatment for advanced renal cell carcinoma.
"Despite recent advances in the treatment of advanced kidney cancer, there is a clear need for additional treatment options for patients whose disease has progressed following first-line medications," Rothenberg added.
The oral therapy was designed to selectively inhibit tyrosine kinases, including vascular endothelial growth factor (VEGF) receptors 1, 2 and 3, which can influence tumor growth, vascular angiogenesis, and progression of cancer.
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Transplant experts question impact of Facebook's organ-donor registration push - American Medical News |
American Medical News
“The visibility of it is great,” said Benjamin Hippen, MD, a transplant nephrologist at Carolinas Medical Center in Charlotte, NC “How often do you pull out your driver's license? Almost never. Here, it's almost like walking around with a big 'Donate
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SSSOT Completes 1000 free dialysis treatments - IBNLive.com |
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KOCHI: The Sri Sathya Sai Orphanage Trust (SSSOT) celebrated the completion of 1,000 free dialysis treatments at the Mattancherry Navajeevanam Dialysis Centre.
In the one-and-a-half years of its inception,
the centre has undertaken free lifetime dialysis treatment for 10 patients coupled with free medicines and continued medical support. The free dialysis project started in August 2011 was established at the Gautham Hospital in Panayappilly.
At present, the centre has two dialysis machines and nearly 70 patients every month. The trust is planning to organise its anniversary celebrations. The patrons of the trust requested the agencies and persons supporting them to extend their helping hand in future initiatives.
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Obese Patients Face Higher Risks During Heart Surgery - Ivanhoe |
(Ivanhoe Newswire) -- A new study shows that oxidative stress may put obese patients at an increased risk of developing kidney damage after heart surgery. Oxidative stress generates harmful unstable reactive oxygen molecules. The study is appearing in the upcoming issue of the Journal of the American Society of Nephrology(JASN).
More studies are needed to see if effective antioxidants can help reduce the risk. Acute kidney injury (AKI) affects 5% to 30% of heart surgery patients. AKI is an abrupt decline in kidney function and sometimes arises after heart surgery because the kidneys are deprived of normal blood flow during the procedure.
Frederic Billings IV, MD (Vanderbilt University School of Medicine) and members of his team evaluated information gathered from 445 heart surgery patients, 25% of whom developed AKI. The major findings of the study showed obese patients had an increased risk of developing AKI; and that oxidative stress plays a role in the link between obesity and AKI.
"The identification of oxidative stress during surgery as a possible mechanism for the development of kidney injury following surgery provides an opportunity to develop and test therapeutic treatments for surgical patients," Dr. Billings was quoted as saying.
SOURCE: American Society of Nephrology, May 2012
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Dialysis Patients Threatened by Deadly Infection - Ivanhoe |
New research shows an infection called peritonitis commonly arises in the weeks before many dialysis patients die. The findings suggest that peritonitis may be a deadly condition for some kidney failure patients.
Most kidney failure patients on dialysis get their treatments at a clinic, through hemodialysis. But about 10% to 20% receive treatments at home through peritoneal dialysis, where fluids are first pumped into the abdominal cavity to collect wastes from the blood and are later removed from the body. Unfortunately this fluid can become infected, causing a condition called peritonitis. This occurs as commonly as twice a year to once every five or six years.
Researchers found that compared with the rest of the year, patients were more likely to develop peritonitis during the 120 days prior to their death, and even more so during the final month before their death. Specifically, they were six times as likely to develop peritonitis during the 30 days prior to their death compared with six months earlier.
"We have therefore proposed a potential new definition for a cause of death—"peritonitis-associated death"—being any death within 30 days of an episode of peritonitis," Professor Neil Boudville of the University of Western Australia, Perth was quoted as saying.
SOURCE: Journal of the American Society of Nephrology, May 2012
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