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Hydrogen sulfide generating compound protects stressed mitochondria. |
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Eurekalert: The study was published in the journal Medicinal Chemistry Communications. A follow-up study, published in The Nitric Oxide Journal with collaborators from the University of Texas Medical Branch, also found that the compound selectively prevented mitochondrial DNA in mitochondria. Once damaged, this DNA cannot be repaired, leaving individuals more vulnerable to disease symptoms. Early indications in small-scale studies, presented at this year's 3rd International Conference on Hydrogen Sulfide in Biology and Medicine in Kyoto, also show that in high blood pressure, AP39 reversed blood vessel stiffening and lowered blood pressure. It also dramatically improved chances of survival after a heart attack by slowing the heartbeat, improving its efficiency.
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U. Penn study suggests that donating a kidney does not affect life expectancy. |
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UPENN: The new study matched 3,368 donors 55 years old or older with the same number of healthy non-donors, and followed them for a median of 7.8 years. Each donor was matched to a healthy older adult who was the same race, sex and very close in age. The donors and the matched healthy non-donors had similar life expectancy. In addition, researchers linked the records of the study population to a Medicare database. Among the group with Medicare insurance, donors and healthy non-donors had similar rates of cardiovascular disease and diabetes. The donors did see their primary care doctors more often, but the authors suggest that is likely due to post-donation follow-up care.
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Phase 1 trial launched of antibiotic that targets C. difficile. |
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Eurekalert: The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched an early-stage clinical trial of CRS3123, an investigational oral antibiotic intended to treat Clostridium difficile (C. difficile) infection. CRS3123 (previously known as REP3123) is a narrow-spectrum agent that inhibits C. difficile growth while sparing normal intestinal bacteria.
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Transmission of hepatitis C from blood of patients who were successfully treated. |
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EurekAlert: A recent study in the Journal of Clinical Investigation tested if this reappearing HCV RNA is infectious. Using an animal model, Barbara Rehermann and colleagues at the NIH found that blood from patients with trace amounts of HCV RNA is able to cause HCV infection, though the animals did not immediately show signs of HCV infection.
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Mucor fungus contaminating yogurt may be threat to consumers. |
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EurekAlert: In September 2013, customers of Chobani brand Greek yogurt complained of gastrointestinal (GI) problems after consuming products manufactured in the company's Idaho plant. The company issued a recall, and it was believed at the time that the fungal contaminant Murcor circinelloides was only a potential danger to immunocompromised individuals. However, as complaints of severe GI discomfort continued from otherwise healthy customers, researchers began to question the fungus and its ability to cause harm in healthy humans.
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