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M3 muscarinic receptor on pancreatic beta cells key to insulin release. |
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EurekAlert: "We found that in order to maintain the correct levels of sugar, a protein present on the cells that release insulin in the pancreas has to be active. This protein, called the M3-muscarinic receptor, is not only active but also needs to undergo a specific change. This change triggers insulin release and the control of blood sugar levels." Professor Tobin added: "Without the change in the M3-muscarinic receptor protein sugar levels go up in the same way that we see in diabetes. We are of course testing if the mechanism of controlling sugar levels we have discovered is one of the mechanisms disrupted in diabetes. If this were the case then our studies would have important implications in diabetes."
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Institute of Medicine releases new guidelines for vitamin D intake (600-800 IU) |
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IOM: The majority of Americans and Canadians are getting enough vitamin D and calcium to meet their needs, says a new report from the Institute of Medicine. Most U.S. and Canadian residents up to age 70 need no more than 600 international units, or IUs, of vitamin D per day to maintain health; those 71 and older may need as much as 800 IUs. The daily amount of calcium needed ranges from 700 to 1,300 milligrams based on age.
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Source of protection against saturated fat (Angptl4) found, and 3% of people don't have it. |
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EurekAlert: The data show that Angptl4 is a key player in the protection against the severe proinflammatory effects of dietary saturated fat, the researchers conclude. The findings may have implications for the approximately three percent of the human population who carry a mutation in the Angptl4 gene. "Based on our data in mice, it can be hypothesized that human subjects homozygous for the E40K mutation in Angptl4, which has reduced ability to inhibit LPL and is associated with lower plasma triglycerides, may be particularly sensitive to the proinflammatory effects of dietary saturated fat," the researchers wrote.
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Infection fears prompt screening - BBC News |
BBC News
Hundreds of dialysis patients are to be screened for hepatitis C after two people contracted it during treatment at the same unit in Spain.
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Dialysis center adds convenience - Morgan Hill Times |
Morgan Hill Times
Kidney dialysis is a medical process that artificially replaces the kidneys' function, using machines and drugs to filter the patients' blood.
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