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l o o k i n g + s t a t e m e n t s + h e r e + t o d a y % 2 c + s o + p l e a s e + c o n s u l t + w i t h + a l l + o f + o u r + d o c u m e n t s + f i l e d + w i t h + t h e + s e c % 2 c + u n d e r s t a n d + a l l + t h e + r i s k s + a s s o c i a t e d + w i t h + q u e s t c o r + t h o r o u g h l y + b e f o r e + i n v e s t i n g % 2 c + a s + i + d o + t h a t + a n y w a y % 2 c + s o % 0 a q u e s t c o r + i s + a + b i o p h a r m a c e u t i c a l + c o m p a n y + w e + a r e + f o c u s e d + o n + o n e + k e y + p r o d u c t + c a l l e d + a c t h a r + t h i s + p r o d u c t + h e l p s + p a t i e n t s + w i t h + s e r i o u s + d i f f i c u l t + t o + t r e a t + m e d i c a l + c o n d i t i o n s + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a + p a r t i c u l a r + p r o d u c t + a c t h a r + i s + a p p r o v e d + f o r + 1 9 + i n d i c a t i o n s % 2 c + 1 9 + i n d i c a t i o n s + o n + t h e + l a b e l + a p p r o v e d + b y + t h e + f d a + t h e + k e y + m a r k e t s + c u r r e n t l y + a r e + n e p h r o t i c + s y n d r o m e % 2 c + k i d n e y + c o n d i t i o n % 2 c + m u l t i p l e + s c l e r o s i s % 2 c + e s s e n t i a l + n e r v e s + s y s t e m + c o n d i t i o n % 2 c + a n d + i n f a n t i l e + s p a s m s % 2 c + a + f o r m + o f + e p i l e p s y % 0 a t h e + m a r k e t s + t o g e t h e r + f o r m + a + s e v e r a l + b i l l i o n + d o l l a r + m a r k e t + o p p o r t u n i t y + t h e + c o m p a n y % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + s t r a t e g y + i s + v e r y + s t r a i g h t f o r w a r d % 2 c + s t r a t e g i e s + t o + g r o w + s a l e s + i n + e a c h + o f + t h e s e + k e y + m a r k e t s + a n d + t o + d e v e l o p + o t h e r + u n l a b e l e d + m a r k e t s + f o r + a c t h a r % 2 c + a n d + p a r t i c u l a r l y + r h e u m a t o l o g y + w i l l + b e + t h e + n e x t + a r e a + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + b e + g o i n g + i n t o % 0 a t h e + c o m p a n y + i s + p r o f i t a b l e % 2 c + h a s + e x c e l l e n t + o p e r a t i n g + l e v e r a g e + a n d + h e n c e + i s + c a s h + f l o w + p o s i t i v e + o u r + c a s h + i s + n o w + a t + - - + s i t t i n g + a t + % 2 4 1 3 6 + m i l l i o n + t h i s + i s + n e t + o f + s o m e + p a y m e n t s + t h a t + t h e y + w i l l + b e + m a d e + i n + t h e + n e x t + f e w + d a y s + t o + f o r + t h e + s t o c k + t h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + b e e n + r e p u r c h a s i n g + a c t i v e l y + o v e r + t h e + l a s t + s e v e r a l + w e e k s + w e + - - + b y + c o n t r a s t + w e + h a d + a b o u t + a + % 2 4 0 2 5 + b i l l i o n + j u s t + a + c o u p l e + w e e k s + a g o % 0 a w e + a r e + g o i n g + t o + t a l k + t h r o u g h + t h e s e + f o u r + k e y + m a r k e t s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + s t a r t + w i t h + n e p h r o t i c + s y n d r o m e % 2 c + b e c a u s e + t h a t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + t h e + b i g g e s t + m a r k e t + r i g h t + n o w + a l t h o u g h % 2 c + r h e u m a t o l o g y + p r o b a b l y + w i l l + b e + a + b i g g e r + m a r k e t + e v e n t u a l l y % 2 c + a t + l e a s t + t h e + g r e a t + a m o u n t + o f + o u r + v a l u e + f r o m + o u r + s c r i p t s + i s + c o m i n g + f r o m + n e p h r o t i c + s y n d r o m e % 2 c + c l o s e + r i g h t + b e h i n d + i t + i s + m u l t i p l e + s c l e r o s i s % 2 c + i n f a n t i l e + s p a s m s + i s + a + s m a l l e r + m a t u r e + m a r k e t % 2 c + b u t + a n + i m p o r t a n t + o n e + a n d + t h e n % 2 c + f i n a l l y % 2 c + r h e u m a t o l o g y % 0 a s o + l e t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + t a l k + a b o u t + a c t h a r + a n d + n e p h r o t i c + s y n d r o m e % 2 c + s o + n e p h r o t i c + s y n d r o m e + i s + a + c o n d i t i o n + t h a t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + c h a r a c t e r i z e d + b y + e x c e s s i v e + s w e l l i n g + o f + p r o t e i n + i n t o + t h e + u r i n e % 2 c + c o n d i t i o n + c a l l e d + p r o t e i n u r i a % 0 a i t + i s + a + c o n d i t i o n + w h e r e + b a s i c a l l y + t h e + k i d n e y + i s + n o t + f u n c t i o n i n g % 2 c + t h e + f i l t r a t i o n + i n + t h e + k i d n e y + i s + n o t + f u n c t i o n i n g + p r o p e r l y + a n d + t h e + k i d n e y + i s + h e a d e d + p o t e n t i a l l y + f o r + e n d - s t a g e + r e n a l + d i s e a s e % 2 c + w h i c h + m e a n s + t h a t + t h e + o n l y + o p t i o n + l e f t + t o + a + p a t i e n t + a t + t h a t + p o i n t + t i m e + a r e + d i a l y s i s + a n d + t r a n s p l a n t % 0 a a c t h a r + i s + a p p r o v e d + f o r + t r e a t i n g + t h e + p r o t e i n u r i a + i n + n e p h r o t i c + s y n d r o m e % 2 c + t h e + a c t u a l l y + w o r d i n g % 2 c + t h e + l a b e l + i s + u p + h e r e + o n + t h e + s l i d e % 2 c + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + r a t h e r + l a b o r i o u s + l a b e l % 2 c + b u t + w o r d i n g % 2 c + b u t + b a s i c a l l y + w e + r e f e r + t o + t h i s + i s + t r e a t i n g + n e p h r o t i c + s y n d r o m e + f o r + t h e + p u r p o s e + o f + t o d a y % 0 a t h e r e + i s + a + s i g n i f i c a n t + u n m e t + m e d i c a l + n e e d + h e r e + t h e r e + a r e + v e r y + f e w + t r e a t m e n t + o p t i o n s + t h e + g o a l + o f + t h e r a p y + i s + t o + s i g n i f i c a n t l y + r e d u c e + t h e + l e v e l + o f + p r o t e i n u r i a % 2 c + t h e + g o a l + e i t h e r + 5 0 % 2 5 + o r + t h e + p r i m a r y + g o a l + o f + t h e r a p y + i s + t h e + r e d u c t i o n + o f + 5 0 % 2 5 % 2 c + s e c o n d a r y + g o a l + i s + t h e + r e d u c t i o n + o f + 9 0 % 2 5 % 2 c + a n d + t h o s e + a r e + c a l l e d + p a r t i a l + r e s p o n s e + a n d + c o m p l e t e + r e s p o n s e % 0 a s o + w e + e n t e r e d + t h e + n e p h r o l o g y + m a r k e t + h e r e + a b o u t % 2 c + j u s t + a b o u t + a + y e a r + a g o + b y + h i r i n g % 2 c + i + d o n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + k n o w + t h e + p o i n t e r % 2 c + i s + t h e + p o i n t + o u t + h e r e + o o p s % 2 c + t h a t + d i d n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + w o r k + t h i s + i s + n o t + a + p o i n t e r % 0 a m i k e + m u l r o y % 0 a l e f t + s i d e + d o n % 2 c + % 2 8 i n a u d i b l e % 2 9 + l e f t + s i d e + o f + t h e + p o d i u m % 2 c + h e r e + i s % 0 a d o n + b a i l e y % 0 a t h a n k s + o k a y + s o + w e + s t a r t e d + b a c k + a b o u t + a + y e a r + a g o + w i t h + h i r i n g + o f + f i v e + r e p s % 2 c + s o + w i t h + t h i s + w h o l e + f i v e + a n d + y e l l o w + a r e a s + i s + o n + t h e + c h a r t + a n d + t h a t + - - + t h o s e + f i v e + r e p s + g e n e r a t e d + 4 5 + s c r i p t s + a n d + t h e y + w e r e + t h e n + a b l e + t o + g r o w + t h a t + n u m b e r + i n + t h e + s u b s e q u e n t + q u a r t e r % 0 a w e + t h e n + s t a r t e d + a n + a c t i v i t y + t o + e x p a n d + t h a t + s a l e s + f o r c e + t o + 2 8 + r e p s + a n d + y o u + c a n + s e e + s a l e s + j u m p e d + u p % 2 c + s c r i p t + c o u n t + j u m p e d % 2 c + a n d + j u m p e d + u p + a g a i n + i n + m o s t + r e c e n t + q u a r t e r % 2 c + a n d + w e + a r e + n o w + i n + t h e + m i d d l e + o f + a n o t h e r + e x p a n s i o n % 2 c + w h i c h + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + t a l k + a b o u t + l i t t l e + l a t e r + e x p a n d i n g + t h e + 2 8 + s a l e s + r e p s + u p + t o + 5 8 + s o + s a l e s + h a v e + b e e n + g o i n g + r a t h e r + n i c e l y + t h e r e % 0 a s o + l e t + m e + s w i t c h + t o + m u l t i p l e + s c l e r o s i s + a n d + a c t h a r + h e r e + w e + a r e + t a l k i n g + a b o u t + u s i n g + a c t h a r + a c t h a r + i s + a p p r o v e d + f o r + t h e + t r e a t m e n t + o f + e x a c e r b a t i o n s + a l s o + c a l l e d + r e l a p s e + o r + f l a r e s + a s s o c i a t e d + w i t h + m u l t i p l e + s c l e r o s i s % 0 a a n d + a c t h a r + i s + a p p r o v e d + f o r + f i r s t + l i n e + t r e a t m e n t + b u t + w e + a r e + t a r g e t i n g + a c t h a r + a + s e c o n d + l i n e + t r e a t m e n t + f o r + t h o s e + p a t i e n t s + w h o + d o n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + g e t + t h e + c o m p l e t e + r e s p o n s e + t o + i v + s t e r o i d s % 2 c + w h i c h + i s + g e n e r a l l y + t h e + f i r s t + l i n e + t r e a t m e n t + t h i s + g i v e + y o u + s o m e + s t a t s + h e r e + o n + t h e + s i z e + o f + t h i s + p a t i e n t + p o p u l a t i o n + w h i c h + i n + t e r m s + o f + p e r c e n t a g e s % 0 a t h e r e + i s + p r o b a b l y + s o m e t h i n g + i n + t h e + n e i g h b o r h o o d + o f + a b o u t + 2 0 0 % 2 c 0 0 0 + f l a r e s + a + y e a r + s o + y o u + c a n + w o r k + w i t h + t h e + m a t h + h e r e + t o + s e e + t h a t + t h e r e + i s + a + p r e t t y + s i z a b l e + m a r k e t + r i g h t + n o w % 2 c + w e + a r e + a t + a + r u n + r a t e + o f + a b o u t + 5 % 2 c 0 0 0 + p r e s c r i p t i o n s + a + y e a r + s o + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + a + p l e n t y + o f + h e a d w i n d s % 0 a h e r e + w e + h a v e + a + l i t t l e + b i t + l o n g e r + h i s t o r y + o f + h a v i n g + a + s e l l i n g + e f f o r t + y o u + c a n + s e e + w e + s t a r t e d + - - + w e + a c t u a l l y + s t a r t e d + t h e + s e l l i n g + e f f o r t + h e r e + f o u r + y e a r s + a g o + w i t h + e i g h t + r e p s + a n d + w e + b u i l t + t h a t + u p + o v e r + t i m e + a s + y o u + c a n + s e e + i n + t h i s + c h a r t % 2 c + t h e r e + i s + 7 7 + r e p s + a n d + t h e + p r e s c r i p t i o n + c o u n t + h a s + n o w + g r o w n + t o + a b o u t + 1 % 2 c 0 0 0 + a + q u a r t e r + s o + e a c h + o f + t h e s e + b a r s + i s + a + q u a r t e r % 0 a a n d + o n + t h e + n e x t + c h a r t % 2 c + w e + s e r v e + t h e + s a m e + d a t a + o n + a + m o n t h l y + b a s i s + s o + y o u + c a n + s e e + d u r i n g + - - + f r o m + t h i s + c h a r t % 2 c + s a l e s + w e r e + m o v i n g + a l o n g + d u r i n g + 2 0 1 0 % 2 c + w e + e x p a n d e d + t h e + s a l e s + f o r c e + t o + 7 7 % 2 c + l a t e + i n + 2 0 1 0 % 2 c + s a l e s + t h e n + j u m p e d + t o + a + n e w + l e v e l + a n d + n o w + b e e n + k i n d + o f + f l a t t e n i n g + o u t + w e + a r e + i n + t h e + p r o c e s s + c u r r e n t l y + o f + e x p a n d i n g + t h i s + s a l e s + f o r c e + t o + 1 0 9 + t h a t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + o u r + c o m m e n t + o n + t h o s e + e x p a n s i o n s + a + l i t t l e + b i t % 0 a a c t h a r + a n d + i n f a n t i l e + s p a s m s + t h i s + i s + a n + o l d e r + m a r k e t + f o r + a c t h a r + a c t h a r + h a s + b e e n + t h e + s t a n d a r d + c a r e + f o r + t r e a t i n g + i n f a n t i l e + s p a s m s + f o r + d e c a d e s + a n d + y e a h % 2 c + t h a t + w a s + j u s t + a p p r o v e d + b y + t h e + f d a + i n + l a t e + 2 0 1 0 + b e c a u s e + w e + w e r e + t h e + f i r s t + s p o n s o r + t o + t a k e + t h e + t i m e + a n d + e f f o r t + t o + s p e n d + t h e + m o n e y + t o + t r y + t o + g e t + t h i s + d r u g + a p p r o v e d % 2 c + g e t + a c t h a r + a p p r o v e d + f o r + i n f a n t i l e + s p a s m s % 0 a i n f a n t i l e + s p a s m s + i s + n o t + r e s p o n s i v e + t o + y o u r + s t a n d a r d + a n t i - e p i l e p t i c + d r u g s + a n d + u n s u c c e s s f u l + t r e a t m e n t + w i l l + l e a v e % 2 c + i + t h i n k % 2 c + w i l l + l i k e l y + l e a v e + a n + i n f a n t + i n + a + v e r y + b a d + s h a p e % 2 c + o r p h a n + i n + a + h o s p i c e + c a r e + b y + c o n t r a s t + o r + s u c c e s s f u l + t r e a t m e n t + c a n + l e a v e + t h e + - - + c a n + l e a v e + a n + i n f a n t + - - + c a n + m o v e + a n + i n f a n t + b a c k + t o + b e i n g + t o t a l l y + n o r m a l + s o + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a + p r e t t y + d r a m a t i c + c h a n g e + f r o m + a n + u n s u c c e s s f u l + t o + s u c c e s s f u l + o u t c o m e % 0 a i t + i s + c o n s i d e r e d + a + m e d i c a l + e m e r g e n c y + b e c a u s e + t h e + d e v e l o p m e n t + o f + t h e + p a r t + o f + t h e + b r a i n + h a s + r e a l l y + s t o p p e d + t h e + b r a i n + h a s + s t o p p e d + d e v e l o p i n g + s o + t h e r e + i s + a + s e n s e + o f + u r g e n c y + t h i s + i s + a n + u l t r a + r a r e + d i s o r d e r + t h e r e + i s + o n l y + a b o u t + 1 5 0 0 + p a t i e n t s + a + y e a r + a n d + a b o u t + h a l f + o f + - - + a n d + a c t h a r + p r o b a b l y + h a s + a b o u t + 6 0 % 2 5 + m a r k e t + s h a r e + h e r e % 0 a a n d + h a l f + o f + t h a t + 6 0 % 2 5 + o f + p a t i e n t s + a r e + t r e a t e d + e i t h e r + t h r o u g h + f r e e + d r u g + p r o g r a m s + o r + t h r o u g h + m e d i c a i d % 2 c + w h i c h + i s + w h e r e + a c t h a r + h a s + 1 0 0 % 2 5 + r e b a s e + s o + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + b a s i c a l l y + a l s o + a + f r e e + d r u g + p r o g r a m % 0 a i s + s c r i p t s + t e n d s + t o + r u n + t h o r o u g h l y + f l a t + a n d + a p p r o x i m a t e l y + 9 0 + t o + 1 0 0 + r a n g e + a + q u a r t e r + a n d + a c t h a r + i s + - - + t h e + l a s t + t h r e e + q u a r t e r s + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + b e e n + r u n n i n g + a + l i t t l e + b i t + a b o v e + t h a t + a c t h a r + i s + c h a r a c t e r i z e d + b y + a + b r a i n + p a t t e r n + c a l l e d + h y p s a r r h y t h m i a + a n d + t h i s + w i l l + - - + w a v y + p a t t e r n + o n + t h i s + c h a r t + i s + a c t u a l l y + w h a t + a n + e e g + w o u l d + l i k e + f o r + a + b a b y + f o r + i n f a n t i l e + s p a s m s + a n d + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + n o t + i f + y o u + l o o k + l i k e + t h a t % 0 a r h e u m a t o l o g y % 2 c + a c t h a r + h a s + s o m e + - - + h a s + a + p r e t t y + e x t e n s i v e + l a b e l + f o r + r o o m + f o r + v a r i o u s + r h e u m a t o l o g y + i n d i c a t i o n s + i + h a v e + l i s t e d + f o u r + h e r e + t h a t + a r e + r a t h e r + a r e + t h e + m o s t + i n t e r e s t i n g + l u p u s + c o n d i t i o n + c a l l e d + p m d m + o r + p o l y m y o s i t i s % 2 f d e r m a t o m y o s i t i s % 2 c + p s o r i a t i c + a r t h r i t i s + a n d + r h e u m a t o i d + a r t h r i t i s % 0 a a g a i n + t h e r e + i s + a + h i g h + u n m e t + n e e d + i t + i s + d i f f i c u l t + t o + t r e a t + c o n d i t i o n s + t h e r e + i s + s e r i o u s + h e a l t h + i s s u e s + i n v o l v e d + a n d + s i g n i f i c a n t + p a t i e n t + p o p u l a t i o n + a n d + w e + b e l i e v e + t h e r e + a r e + m u l t i - b i l l i o n + d o l l a r + o p p o r t u n i t y + w e + h a v e + v e r y + l i t t l e + s a l e s + i n + t h a t + r h e u m a t o l o g y % 2 c + j u s t + a + h a n d f u l + o f + s c r i p t s + b u t + w e + w i l l + b e + e n t e r i n g + t h i s + m a r k e t + l a t e r + t h i s + y e a r % 0 a w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + t a l k + b r i e f l y + a b o u t + t h e + f i n a n c i a l s % 2 c + t h e n + i % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + s h i f t + t o + s t r a t e g y + s o + t h e + c o m p a n y + h a s + a + p r o f i t a b l e + d e b t + f r e e + c a s h + f l o w + p o s i t i v e + t h e r e + i s + n o t + w h o l e + l o t + t o + t a l k + a b o u t + h e r e + y o u + c a n + s e e + o n + t h i s + c h a r t + t h a t + o u r + s h i p p e d + v i a l s + a r e + g r o w i n g + t h e y + a r e + r o u g h l y + u p + 1 0 0 % 2 5 + y e a r - o v e r - y e a r % 2 c + i f + y o u + l o o k + a t + q 1 + % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 8 1 2 + v e r s u s + q 1 + % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 8 1 1 + o u r + f i n a n c i a l + r e s u l t s + f o r + q 1 % 2 c + w h e r e + s i m i l a r + s a l e s + w e r e + u p + o v e r + 1 0 0 % 2 5 % 0 a e p s + w a s + a l s o + u p + w e l l + o v e r + 1 0 0 % 2 5 % 2 c + i n + f a c t + o v e r + 2 0 0 % 2 5 + t h e + f i r s t + q u a r t e r + c a s h + f l o w + w a s + a b o u t + - - + f r o m + o p e r a t i o n s % 2 c + f r e e + c a s h + f l o w + w a s + a b o u t + % 2 4 4 0 + m i l l i o n % 2 c + o p e r a t i n g + i n c o m e + e p s + o n + t h i s + c h a r t % 0 a w e + d i d + h a v e + a + c h a n n e l + i n v e n t o r y + i s s u e + i n + q 1 + w e + h a d + a + l a t e + o r d e r + o n + t h e + l a s t + d a y + o f + t h e + m o n t h + t h a t + g o t + s k e w e d + i t + w a s + a b o u t + a + % 2 4 4 + m i l l i o n + o r d e r + o f + s a l e s + i n + q 1 + a r e + i n f l a t e d + b y + a b o u t + % 2 4 4 + m i l l i o n + o v e r + - - + d u e + t o + i n v e n t o r y % 0 a s o + a c c o u n t i n g + r u l e s + r e q u i r e + u s + t o + r e c o g n i z e + o u r + r e v e n u e + b u t + j u s t + f o r + y o u r + u n d e r s t a n d i n g + o f + t h e + q u a r t e r % 2 c + o u r + m e d i c a i d + r e s e r v e s + w e r e + n o r m a l + a n d + d u r i n g + q 1 % 2 c + w e + b o u g h t + b a c k + a b o u t + 8 0 0 % 2 c 0 0 0 + s h a r e s + a l t h o u g h + w e + a n n o u n c e d + t h i s + m o r n i n g + w e + b o u g h t + b a c k + a n o t h e r + 3 + m i l l i o n + s o + f a r + i n + q 2 % 0 a i + w i l l + t a l k + a b o u t + t h a t + n o w + s o + i n + t h e + l a s t + f o u r + y e a r s % 2 c + w e + h a v e + r e p u r c h a s e d + 1 9 + m i l l i o n + s h a r e s + w e + n o w + h a v e + 6 0 + m i l l i o n + o u t s t a n d i n g + s o + t h i s + i s + a + 2 6 % 2 5 % 2 c + i s + t h a t + r i g h t + m i k e % 2 c + a b o u t + 2 6 % 2 5 + o f + o u r + s h a r e s % 2 c + 2 7 % 2 5 + o f + o u r + s h a r e s + w e r e + r e p u r c h a s e d + w e + h a v e + 5 4 + m i l l i o n + s h a r e s + r e m a i n i n g + w e + j u s t + e x t e n d e d + o r + j u s t + a d d e d + a n o t h e r + i n c r e m e n t a l + b u y b a c k + p r o g r a m % 0 a w e + h a v e + r e t u r n e d + % 2 4 2 3 6 + m i l l i o n + w o r t h + o f + o u r + f r e e + c a s h + f l o w + t o + s h a r e h o l d e r s + s o + t h e + r e p u r c h a s e + a c t i v i t y + t h i s + y e a r + i s + 3 8 + m i l l i o n + s h a r e s % 2 c + 8 0 0 % 2 c 0 0 0 + i n + q 1 % 2 c + 3 + m i l l i o n + i n + q 2 + a n d + w e + h a d + t h e + m o r e + a g g r e s s i v e + b u y b a c k + n o w + b e c a u s e + i n + t h e + l a s t + s i x + m o n t h s % 2 c + o u r + s a l e s + a n d + e a r n i n g + h a v e + b e e n + i n c r e a s i n g + r a p i d l y % 0 a w e + a r e + n o w + s e e i n g + s o m e + t r a c t i o n + i n + t h e + n e p h r o l o g y + m a r k e t + t h e + s a l e s + f o r c e + e x p a n s i o n + i s + g o i n g + v e r y + w e l l + i n + f a c t % 2 c + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + r u n n i n g + w e l l + a h e a d + o f + s c h e d u l e + a n d + w e + a r e + g e t t i n g + r e a d y + t o + m o v e + i n t o + t h e + r h e u m a t o l o g y + o p p o r t u n i t y % 0 a s o % 2 c + i + t h i n k % 2 c + a s + y o u + a l l + w o u l d + k n o w % 2 c + r e p u r c h a s e d + s h a r e s + a r e + a c c r e t i v e % 2 c + h i g h l y + a c c r e t i v e + s i n c e + i n t e r e s t + w e + c a n + e a r n + o n + t h a t + c a s h + i s + b a s i c a l l y + n e a r + z e r o + t h e + q 1 + - - + j u s t + i n + q 1 + a l o n e % 2 c + b a s e d + o n + t h e + r e p u r c h a s e + a c t i v i t y + u p + t h r o u g h + q 1 % 2 c + s o + t h a t + d o e s n % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 t + i n c l u d e + w h a t + h a p p e n e d + i n + q 2 + w e + e s t i m a t e + i t + h a s + i n c r e a s e d + e p s + b y + 2 4 % 2 5 + s o % 2 c + i f + w e + h a d + n o t + d o n e + a n y + o f + t h i s + a c t i v i t y % 2 c + e p s + w o u l d + h a v e + b e e n + i m p a c t e d + b y + 2 4 % 2 5 + i n + q 1 % 0 a o u r + b a l a n c e + s h e e t + i s + v e r y + s t r a i g h t f o r w a r d + i t + j u s t + h a s + c a s h + a n d + e q u i t y + o n + i t + a n d + y o u + c a n + s e e + t h e + c a s h + i s + % 2 4 1 3 6 + m i l l i o n % 2 c + n e t + o f + t h e + f i n a l + p a y m e n t s + o u t + o n + s h a r e + r e p u r c h a s e % 0 a w e + r e p o r t e d + r e c e n t l y + o u r + a p r i l + m e t r i c s % 2 c + s o + w e + r e p o r t + m o n t h l y + o u r + s c r i p t + a c t i v i t y + a n d + h e r e + i t + i s + f o r + - - + t h e r e + i s + n o t h i n g + n e w + o n + t h i s + p a g e + w e + s h i p p e d + 1 % 2 c 3 5 0 + v i a l s + i n + a p r i l + e v e n + w i t h + t h e + c h a n n e l + i s s u e + b u t + t h e + e n d i n g + l e v e l + o f + i n v e n t o r y + a t + t h e + e n d + o f + a p r i l + i s + s t i l l + o n + t h e + h i g h + s i d e % 2 c + n o t + q u i t e + a s + h i g h + a s + i t + w a s + a t + t h e + e n d + o f + m a r c h % 2 c + b u t + s t i l l + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + o n + h i g h + s i d e % 0 a w e + a l s o + a n n o u n c e d + t h a t + o p e r a t i n g + e x p e n s e s + i n + q 2 + a r e + e x p e c t e d + t o + b e + u p + a b o u t + % 2 4 1 0 + m i l l i o n + o v e r + q 1 + a n d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + u p + a g a i n + i n + q 3 + t h i s + i s + p r i n c i p a l l y + r e l a t e d + t o + t h e % 2 c + a l l + t h e + s a l e s + f o r c e + e x p a n s i o n s + w e + a l s o % 2 c + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 l l + a n n o u n c e + t o d a y + t h a t + w e + t o o k + a + s m a l l + p r i c e + i n c r e a s e + e f f e c t i v e + t o d a y % 0 a a c t h a r + i s + a + v e r y + i n t e r e s t i n g + d r u g + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a n + o l d + d r u g + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + n o t + w e l l + u n d e r s t o o d + h o w + t h i s + d r u g + w o r k s + i t + a p p e a r s + t o + m o d e r a t e + t h e + a u t o i m m u n e + s y s t e m + i t + w o r k s + v e r y + n i c e l y + i n + a + n u m b e r + o f + d i f f e r e n t + o f + t h e s e + a u t o i m m u n e + c o n d i t i o n s + a s + y o u + c a n + j u s t + s e e + f r o m + w h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + t a l k e d + a b o u t + s o + f a r % 2 c + r h e u m a t o l o g y % 2 c + k i d n e y s + a n d + c e n t r a l + n e r v o u s + s y s t e m s % 2 c + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + q u i t e + a + w i d e + v a r i e t y % 0 a a c t h a r + w o r k s + - - + t e c h n i c a l l y + w e + b e l i e v e + i t + w o r k s + t h r o u g h + t h e + m e l a n o c o r t i n + p e p t i d e + s y s t e m + t h e r e + a r e + a + n u m b e r + o f + r e c e p t o r s + l o c a t e d + t h r o u g h o u t + o r g a n s + i n + t h e + b o d y + a c t h a r + s e e m s + t o + a c t i v a t e + t h o s e + r e c e p t o r s % 2 c + w h i c h + t h e n + m o d u l a t e + t h e + i m m u n e + s y s t e m % 0 a a l l + t h e + c o n t e n t s + o f + a c t h a r + a n d + i t s + e f f e c t i v e + i n g r e d i e n t s + h a v e + y e t + t o + b e + t o t a l l y + c h a r a c t e r i z e d + w e + a r e + i n + t h e + p r o c e s s + o f + d o i n g + t h a t + t h e + p k + p r o f i l e + i s + n o t + i n + t h e + p u b l i c + d o m a i n + a n d + t h a t + i s + n o t + w e l l + k n o w n + s o + n o n e + o f + t h i s + w i l l + e v e r + b e e n + m a d e + p u b l i c + s o + b a s i c a l l y + t h e s e + a r e + a l l + t r a d e + s e c r e t s + t h a t + p r o v i d e + s o m e + p r e t t y + s i g n i f i c a n t + h u r d l e s + t o + a + c o m p e t i t o r + t o + e v e r + d u p l i c a t e + t h i s + d r u g % 0 a w e % 2 c + t h e r e f o r e + t h i n k + t h a t + a + b i o s i m i l a r + o r + g e n e r i c + p a t h w a y + a r e + e x t r e m e l y + d i f f i c u l t % 2 c + i f + n o t + i m p o s s i b l e % 2 c + b e c a u s e + t h e + d r u g + i s + n o t + w e l l + c h a r a c t e r i z e d % 2 c + c o m p l e x + p h a r m a c o l o g y % 2 c + n o t + k n o w n + h o w + t h e + d r u g + w o r k s + p u b l i c l y % 0 a s o + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + b e l i e v e + c l i n i c a l + t r i a l s + w i l l + b e + i n v o l v e d + f o r + a n y + c o m p e t i t o r + a n d + t h a t + w o u l d + b e + i n d i c a t i o n s + s p e c i f i c + s o % 2 c + s o m e + o f + o u r + r i s k + a b a t e m e n t + h e r e + i s + h a v i n g + s o u r c e s + o f + r e v e n u e + f r o m + m u l t i p l e + t h e r a p e u t i c + a v e n u e s % 0 a l e t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + t a l k + b r i e f l y + a b o u t + t h e + m a r k e t + o p p o r t u n i t y % 2 c + j u s t + f r o m + w h a t + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + - - + j u s t + f r o m + t h e + i n d i c a t i o n s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + a l r e a d y + i d e n t i f i e d + s o + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + t a l k e d + m s % 2 c + n e p h r o t i c + s y n d r o m e % 2 c + i n f a n t i l e + s p a s m s + a n d + r h e u m a t o l o g y + a n d + y o u + c a n + s e e + h e r e + t h a t + t h e + r x s + v a l u e s + v a r y % 2 c + s o + a + p r e s c r i p t i o n + f o r + a c t h a r % 2 c + f o r + m s + i s + i n + t h e + % 2 4 4 0 + t o + % 2 4 5 0 % 2 c 0 0 0 + r a n g e % 2 c + f o r + n e p h r o l o g y + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + m u c h + h i g h e r % 0 a a n d + t h e + m a r k e t + s i z e + i s + o v e r + t h e r e + i n + t h e + r i g h t + a r e % 2 c + t h e s e + a r e + n u m b e r s + w h e r e + t h e + m a r k e t s + c e r t a i n l y + s u s t a i n e d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + b e e n + v e r y + c o n s e r v a t i v e + i n + s t a t i n g + t h e s e + n u m b e r s + o u r + r u n + r a t e + o f + s a l e s + h e r e + i s + a b o u t + s o m e w h e r e + b e t w e e n + % 2 4 3 5 0 + m i l l i o n + t o + % 2 4 4 0 0 + m i l l i o n % 2 c + s o + y o u + c a n + s e e + w h e r e + w e + a r e + v e r s u s + t h e s e + m a r k e t + o p p o r t u n i t i e s % 0 a w e + w a n t + t o + p o i n t + o u t + t h a t + i n + t h e + c a s e + o f + n e p h r o t i c + s y n d r o m e + w e + d o n % 2 7 t + g i v e + a l l + t h e + r e v e n u e + i n + t h e + q u a r t e r + i n + w h i c h + t h e + s c r i p t + c o m e s + i n + f o r + m s + a n d + i s + w h e n + t h e + s c r i p t + c o m e s + i n % 2 c + p r e t t y + m u c h % 2 c + a l l + t h e + v i a l s + a r e + s h i p p e d + r i g h t + a w a y + a n d + t h e y + a r e + c o n s u m e d + i n + a + v e r y + s h o r t + p e r i o d + o f + t i m e % 2 c + a + w e a k + o r + t w o % 0 a n e p h r o t i c + s y n d r o m e + i s + a + s i x - m o n t h + s c r i p t + a n d + t h e + v i a l s + t e n d + t o + g o + o u t + o v e r + a + s i x - m o n t h + p e r i o d % 2 c + a n d + t h e + r e v e n u e + i s + g o i n g + t o + t r a c k + w i t h + t h e + v i a l s + t h r o u g h + a n + i n v e n t o r y + c u s h i o n + s o % 2 c + w h e n + t h e + s c r i p t + c o m e s + i n + f o r + n e p h r o t i c + s y n d r o m e % 2 c + t h e + v a l u e + o f + t h a t + s c r i p t + i s + o b v i o u s l y + g o i n g + t o + e v e n t u a l l y + b e + r e c o g n i z e d + a s + t h e + s c r i p t + i s + f u l f i l l e d + b u t + i n + t h e + m o s t + r e c e n t + t i m e + p e r i o d % 2 c + t h e + r e v e n u e + w o u l d + b e + a + l i t t l e + b i t + l o w e r % 0 a s o + h e r e % 2 7 s + o u r + p l a n + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + a + v e r y + s t r a i g h t f o r w a r d + p l a n + o u r + p l a n + i s + t o + f o c u s + o n + a c t h a r + a n d + t o + f o c u s + o n + t h e + e m b e d d e d + p i p e l i n e + s o + w e + w a n t + t o + e x p a n d + o u r + n e p h r o t i c + s y n d r o m e + e f f o r t + a n d + i + w i l l + t a l k + a + l i t t l e + b i t + m o r e + a b o u t + t h a t + i n + a + m i n u t e + w e + w a n t + t o + e x p a n d + t h e + m s + p r o m o t i o n + e f f o r t % 0 a i s + i s + p r e t t y + m u c h + i n + a + m a t u r e + s t a g e % 2 c + s o + t h e r e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + n o t + m u c h + t o + d o + t h e r e + a n d + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + g o i n g + t o + i n i t i a t e + a + p i l o t + e f f o r t + i n + r h e u m a t o l o g y % 2 c + l i k e + t h e + t w o + p i l o t s + w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 v e + d o n e + i n + t h e + p a s t + f o r + m s + a n d + n e p h r o t i c + s y n d r o m e % 0 a w e % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 r e + a l s o + g o i n g + t o + d e v e l o p + o t h e r + m a r k e t s + f o r + a c t h a r + w e + w a n t + t o + l o o k + f i r s t + a t + t h e + o t h e r + o n - l a b e l + i n d i c a t i o n s % 2 c + w h i c h + a r e + m a i n l y + i n + t h e + d e r m a t o l o g y + a n d + o p h t h a l m o l o g y + a r e a s + a n d + w e + w a n t + t o + f u r t h e r + d e f i n e + t h e + u n i q u e + c h a r a c t e r i s t i c s + o f + a c t h a r % 2 c + s o + t h a t + w e + c a n + u n d e r s t a n d + t h e + d r u g + b e t t e r + a n d + l o o k + a t + o t h e r + p o s s i b l e % 2 c + f u t u r e + i n d i c a t i o n s + f o r + a c t h a r + t h a t + c o u l d + b e + a d d e d + t o + t h e + l a b e l + a f t e r + t r i a l s + a r e + r u n % 0 a w e + d o + n o t + p l a n + o n + d o i n g + a n y + b u s i n e s s + d e v e l o p m e n t + o r + a c q u i s i t i o n s + c e r t a i n l y % 2 c + u n l e s s + i t % c 3 % a 2 % c 2 % 8 0 % c 2 % 9 9 s + r e a l l y + c l o s e l y + r e l a t e d + t o + t h i s + p i t u i t a r y + a d r e n a l + a x i s % 0 a t h e + s a l e s + f o r c e + e x p a n s i o n + l o o k s + a + l i t t l e + b i t + l i k e + t h i s + t i m e - 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