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TH17 blocking drug halts multiple sclerosis in animal models, may also affect lupus. |
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EurekAlert: For the past several years, Burris and his colleagues have been investigating small-molecule compounds that affect particular disease-related receptors (structures that bind other molecules, triggering some effect on the cell). In particular, the scientists have been interested in a pair of "orphan nuclear receptors" (receptors with no known natural binding partner) called ROR? and ROR? involved in both autoimmune and metabolic diseases.
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