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Defect in CD8 regulatory T cells linked to lupus in a mouse model. |
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Jackson Laboratory: Using a mouse model for systemic lupus erythematosus in humans that was originally discovered at 30 years ago by Edwin Murphy at The Jackson Laboratory, the Dana-Farber researchers, working with Roopenian’s laboratory, found defects in CD8+ Treg activity. The new paper, Roopenian explains, is the first to demonstrate the potential breakdown of this suppression mechanism in lupus. “Overcoming this defect,” he says, “offers a potential approach prevent lupus.”
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